The average lifespan of a Berner is slightly more than seven years, with some individuals living to ten years and beyond.

Bernese Mountain Dogs are susceptible to certain health problems thought to be typical of the breed including hip dysplasia, cancer, bloat, sub-aortic stenosis, autoimmune diseases, skin and coat problems, thyroid disorders, von Willebrand's disease and eye disorders (ectropian, entropion, cataracts, PRA).

Although some of these conditions are known to be hereditary, nutrition and other environmental factors may influence the development of some diseases (this is true for any breed).

Responsible breeders screen their dogs for the more common genetically transmitted disorders; however, none of the currently available tests are absolutely foolproof, and even cleared parents may produce an affected offspring. Breeders and owners are encouraged to report health information to the Berner-Garde open database and to use it's vast databank.